More Effective Ways to Understand the Syringe Filter

A Syringe filter is a single-use filter cartridge. It attaches to the end of a syringe. You will generally find syringe filters with Luer- lock fittings. In this mechanism, the use of a needle is optional. It means if you need the needle, it may fit the end of the syringe filter. In today’s competitive world, rapid sample production is necessary. A Syringe Filter usually consists of a plastic housing with a membrane. This membrane works as a filter. The body of the syringe filter may be made from polypropylene and nylon, etc any products. Its filter membrane may be of PTEE, nylon, or other related products.

It seems that most manufacturers, like Simsii Inc, provide compatibility charts. It advises users of compatibility between their products and organic solvents that are called corrosive liquids. A syringe filter can use to remove particles from the sample before examination by the HPLC. Particles can damage an HPCL due to the narrow bore and high pressure. Syringe filters are most preferential and suitable for Schlenk line work. The Schlenk line work uses, extensively, needles and syringes. Syringe filters are comparatively affordable and used in volumes for general purposes. This blog will discuss the more effective ways to understand the PTFE Syringe Filter.

Bubble Point

The bubble point test considers a non-destructive test. It means it does not contaminate the filter. It also uses to test the integrity of a membrane or filter. It works as an alternative to destructive tests such as bacterial retention tests for sterilizing membranes. This test detects any minor filter defects and also out-of-size pores. It also correlates with the bacteria passage test. Simply, an in-process bubble point test examines the damaged membranes, ineffective seals, and system leaks and distinguishes filter pore size.

Syringe Filter Size

The size of syringe filters lies between 4 mm to 50 mm. In simple terms, the diameter of the filter would be so the ratio of particles can capture on its surface. The size of the syringe filter depends on the diameter of the membrane filter which fits inside it.

The Pore Size

The size of the membrane pore is equal to the size of the filter syringe. It also depends on the size of the things you want to remove from the reagent. Some popular membrane pore sizes are 0.2, 0.45, and 0.8 diameters.

Sterilization

The Syringe Filter companies adopt two methods to give a syringe filter sterilization. These methods are ethylene oxide sterilization and gamma irradiation sterilization. The ethylene oxide sterilization method is a chemical process that consists of four primary variables. These are gas concentration, humidity, temperature, and time. In the gamma irradiation sterilization process, the radioisotope cobalt 60 considers the primary energy source.

Uses of Different Materials

For preparing a Syringe Filter companies can use different materials. These are as follows.

Cellulose Acetate (CA) is a quite-low protein binding membrane. CA considers ideal for aqueous-based samples and biological samples. It is a strong membrane mechanically and hydrophilic.

Gass Fiber or microfiber (GF) filters can use as a pre-filter for samples with high particulate content. The GF membranes are available with a bigger pore size than others and more tolerant to most solvents.

Nylon (NY) membrane has comparatively high mechanical strength and chemical stability. The NY membranes can tolerate most organic solvents.

Conclusion

The above given are a few Syringe Filter membrane-making materials. You can add polyethersulphone (PES), polypropylene (PP), polytetrafluoroethylene (PTFE), polyvinylidene difluoride (PVDF), and regenerated cellulose (RC) to this list. We should add a luer lock to understand it in a better way. The luer lock is a standardized system for small-scale fluid fittings to make it leak-proof.