All Information About Paracetamol

Antidote for fever

Sanjeyan N

6 months ago|3 min read


Mechanism of action

The activation of descending serotonergic inhibitory pathways in the CNS is thought to be responsible for the analgesic effects. It's also possible that interactions with other nociceptive systems are involved. The hypothalamic heat-regulating center is inhibited, resulting in antipyresis.

Dosage Forms:

Capsule, Oral: 500 mg, 325 mg

Elixir, Oral: 160 mg/5 mL

Gel, Oral: 160 mg/5 mL

Liquid, Oral: 500 mg/15 mL

Suppository: 120 mg, 325 mg, 650 mg


Onset of action:

Oral: <1 hour

IV: Analgesia: 5 to 10 minutes; Antipyretic: Within 30 minutes

Peak effect: IV: Analgesic: 1 hour


IV, Oral: Analgesia: 4 to 6 hours

IV: Antipyretic: ≥6 hours


~1 L/kg at therapeutic doses

Protein binding:

10% to 25% at therapeutic concentrations; 8% to 43% at toxic concentrations


At therapeutic doses, primarily hepatic metabolism to sulfate and glucuronide conjugates, with a small amount metabolized by CYP2E1 to a highly reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is rapidly conjugated with glutathione and inactivated to nontoxic cysteine and mercapturic acid conjugates. Glutathione conjugation becomes insufficient to meet metabolic demand at toxic doses (as low as 4 g daily), resulting in an increase in NAPQI concentrations, which may cause hepatic cell necrosis. First-pass metabolism affects oral administration.

Half-life elimination: Prolonged following toxic doses

Neonates: 7 hours (range: 4 to 10 hours)

Infants: ~4 hours (range: 1 to 7 hours)

Children: 3 hours (range: 2 to 5 hours)

Adolescents: ~3 hours (range: 2 to 4 hours)

Adults: ~2 hours (range: 2 to 3 hours); maybe slightly prolonged in severe renal insufficiency (CrCl<30 mL/minute): 2 to 5.3 hours

Time to peak, serum: Oral: Immediate release:

10 to 60 minutes (maybe delayed in acute overdoses); IV: 15 minutes


Urine (<5% unchanged; 60% to 80% as glucuronide metabolites; 20% to 30% as sulphate metabolites; ~8% cysteine and mercapturic acid metabolites)

Adverse Reactions

Oral, Rectal: Frequency not defined:

Otic: Hearing loss

Dermatologic: Skin erythema, skin blisters, skin rash Dermatologic: Skin erythema, skin


>10%: Gastrointestinal: Nausea (34% in adults, 5% in neonates, infants, children, and adolescents), vomiting (15% in adults, 5% in neonates, infants, children, and adolescents).

1% to 10%:

Hypertension, hypotension, and peripheral edema are all symptoms of cardiovascular disease (adults)

Pruritus (5% of newborns, infants, children, and adolescents) Dermatologic

Hypoalbuminemia (neonates, infants, children, and adolescents), hypokalemia, hypomagnesemia (neonates, infants, children, and adolescents), hypophosphatemia are all endocrine and metabolic disorders (neonates, infants, children, and adolescents)

Constipation (neonates, infants, children, and adolescents: 5%), diarrhea (neonates, infants, children, and adolescents: 5%). (neonates, infants, children, and adolescents)

Oliguria is a genitourinary condition (neonates, infants, children, and adolescents)

Oncologic & hematologic: Anemia

Serum aspartate aminotransferase levels are higher in the liver (Watkins 2006)

Local: Infusion site pain, injection site pain

Nervous system: agitation (infants, children, and adolescents), anxiety (adults), fatigue (adults), headache, insomnia (adults: 7%), and trismus (neonates, infants, children, and adolescents) (adults)

Muscle spasm (1%), neuromuscular & skeletal:

Respiratory problems include abnormal breath sounds (in adults), atelectasis (in neonates, infants, children, and adolescents), dyspnea (in adults), pleural effusion (in neonates, infants, children, and adolescents), pulmonary edema (in neonates, infants, children, and adolescents), stridor (in adults), and wheezing.


Concerns about diseases:

 • G6PD deficiency: Use caution in people who have been diagnosed with G6PD deficiency.

 • Hepatic impairment: In patients with hepatic impairment or active liver disease, use with caution; use of the IV formulation is contraindicated in patients with severe hepatic impairment or severe active liver disease.

 • Hypovolemia: In patients with severe hypovolemia, use the IV formulation with caution (eg, due to dehydration or blood loss).

 Specific Dosage Form Issues:

 • Aspartame: Some products contain aspartame, which is metabolized to phenylalanine and should be avoided (or used with caution) by phenylketonuria patients.

 •Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol and/or sodium benzoate/benzoic acid; benzoic acid (benzoate) is a benzyl alcohol metabolite.

Dietary Suggestions

Phenylalanine and/or sodium may be present in some products.


Injection: Refrigerate or freeze intact vials and bags at 20°C to 25°C (68°F to 77°F). Some products require light protection.

Oral formulations should be stored at 20°C to 25°C (68°F to 77°F); excessive heat (40°C [104°F]) should be avoided. High humidity should be avoided (chewable tablets).

 Suppositories: Do not freeze; store at 2°C to 27°C (25°F to 80°F).


Sanjeyan N




Read More